Anti-Melanogenesis and Anti-Photoaging Effects of the Sulfated Polysaccharides Isolated from the Brown Seaweed Padina boryana

Sulfated polysaccharides isolated from seaweeds are thought of as ideal ingredients in the pharmaceutical, nutraceutical, and cosmetics industries. Our previous study characterized sulfated Padina boryana. The boryana (PBP) were extracted, antioxidant activity PBP was evaluated. results indicate that possesses effects potential cosmetic industry. To further investigate cosmetics, photoprotective anti-melanogenesis test display reduced melanin content murine melanoma cells stimulated by alpha melanocyte-stimulating hormone 203.7% to 183.64%, 144.63%, 127.57% at concentrations 25 μg/mL, 50 100 respectively. anti-photodamage showed significantly protected skin against UVB-stimulated photodamage. suppressed human epidermal keratinocyte (HaCaT cell) death inhibiting apoptosis reducing level intracellular reactive oxygen species. species HaCaT irradiated UVB 192.67% 181.22%, 170.25%, 160.48% μg/mL PBP, In addition, remarkably UVB-induced dermal fibroblast damage suppressing oxidative damage, collagen degradation, attenuating inflammatory responses. These activities suggest is a ingredient